Bioinformatic identification of Mycobacterium tuberculosis proteins likely to target host cell mitochondria: virulence factors?

Table 3 Comparative analysis of some M. tuberculosis CDC1551 strain PE and PE_PGRS proteins with their H37Ra, H37Rv and BCG Pasteur strain orthologes

	CDC 1551	H37Ra	H3TRv	BCG Pasterur 1173P2
	MT_0118	MRA_0115	Rv0109	BCG_0142
Putative identity	PE–PGRS family protein
% Similarity		81.4	81.4	81.4
MITOPROT II
Score	0.9796	0.1144	0.9799	0.1144
PSORT II Score	82.6%	11.1%	82.6%	11.1%
Signal P Score	0.988	0.999	0.998	0.999
	MT_0349	MRA_0344	Rv0335c	BCG_0374
Putative identity	PE family protein
% Similarity		81.9%	81.9%	81.3%
MITOPROT II
Score	0.9902	0.0157	0.9746	0.0155
PSORT II Score	73.9%	17.4%	69.6%	21.7%
Signal P Score	0.640	NS	NS	NS
	MT_0854	MRA_0841	Rv0832	BCG_0885
Putative identity	PE–PGRS family protein
% Similarity		56.2%	56.2%	56.2%
MITOPROT II
Score	0.9326	0.4901	0.5935	0.5738
PSORT II Score	73.9%	4.3%	8.7%	11.1%
Signal P Score	0.999	0.998	0.993	0.998
	MT_1886	MRA_1830	Rv1818c	BCG_1853c
Putative identity	PE–PGRS Family
% Similarity		53.4%	53.4%	53.4%
MITOPROT II
Score	0.9983	0.1494	0.1494	0.1475
PSORT II Score	73.9%	13.0%	13.0%	13.0%
Signal P Score	0.974	0.991	0.991	0.991
	MT_2690	MRA_2643	Rv2615c	BCG_1035c
Putative identity	PE–PGRS Family
% Similarity		79.0%	79.0%	78.2%
MITOPROT II
Score	0.9472	0.9472	0.8178	0.9488
PSORT II Score	52.2%	52.2%	13.0%	52.2%
Signal P Score	0.917	0.917	0.849	0.917
NS non signal