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Table 2 Known and estimated sizes of interactomes

From: Mycobacterium tuberculosis and Clostridium difficille interactomes: demonstration of rapid development of computational system for bacterial interactome prediction

Organism Number of proteins number of pairs Upper estimate of number of interactions Lower estimate of number of interactions Currently known interactions % relative to larger estimate of interactome size % relative to smaller estimate of interactome size
Mtb 4,020 8,078,190 16,156 5,385 3,439* 21 62
CD 4,147 8,598,804 17,197 5,732 3,414* 20 60
Yeast 6,717 22,555,686 45,111 15,037 37,000 [34] 82 246
Human 22,500 253,113,750 506,228 168,743 38,000 [35] 8 23
  1. Number of proteins and the size of the interactome are shown for human, yeast, Clostridium difficile and Mycobacterium tuberculosis. Upper estimate of interactome size is obtained by considering that one in 500 random pairs is an interacting pair, and lower estimate is obtained by considering that one in 1500 random pairs is an interacting pair. *These numbers are determined from nonzero STRING experimental scores