The linear mapping clustering for the 109 EV71 VP1 sequences shown on the first and second PCA coordinates. Eleven clusters corresponding to the genogroups/subgenogroups are presented. The legend indicates EV71 VP1 genogroups/subgenogroups, years of isolation for sequences viruses or their deposition to GenBank, and country of origin. Relevant cluster centroids are highlighted in red. Isolate AF 119795 (&), belonging to C/B genogroups, is a result of intergenotypic recombination . Abbreviations: AUS, Australia; CHN, the Chinese mainland; JAP, Japan; MAL, Malaysia; NOR, Norway; SK, South Korea; SA, South Africa; SIN, Singapore; TW, Taiwan; UK, United Kingdom; USA, United States of America.