Table 1 Sequence parameter names and formulae^†

x(e.g., a, c)

Fractional content of residue x

(count of residue x)/(chain length)

x b (e.g., cb, db)

predicted buried amino acid fraction

(number of residue x predicted buried by PHD/PROF)/(chain length)

x e (e.g., de, ee)

predicted exposed amino acid fraction

(number of residue x predicted exposed by PHD/PROF)/(chain length)

gravy

GRAVY/hydrophobicity

mean residue hydrophobicity

sce

sidechain entropy

mean sidechain entropy of all residues

esce

predicted exposed sidechain entropy

mean sidechain entropy of residues predicted exposed by PHD/PROF

numcharge

number of charged residues

R + K + D + E

netcharge

net charge

R + K - D - E

absnetcharge

absolute net charge

|R + K - D - E|

fracnumcharge

fraction of charged residues

(R + D + D + E)/chain length

fracnetcharge

fractional net charge

(R + K - D - E)/(chain length)

fracabsnetcharge

fractional absolute net charge

|R + K - D - E|/(chain length)

diso

fraction predicted disordered residues

(number of amino acids predicted disordered by DISOPRED2)/(chain length)

length

chain length

number of residues

pi

isoelectric point

ExPASy pI (http://ca.expasy.org/tools/pi_tool.html)