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Table 8 Assignment of GO concepts related to stress responses.

From: Stringent response of Escherichia coli: revisiting the bibliome using literature mining

    Frequency of Ontology Annotation
GO Identifier GO Concept GO Description 1970 1980 1990 2000
GO:0042594 Response to starvation A change in state or activity of a cell or an organism as a result of a starvation stimulus, deprivation of nourishment. - 15% 28% 68%
GO:0006974 Response to DNA damage stimulus A change in state or activity of a cell or an organism as a result of a stimulus indicating damage to its DNA. 7% 26% 31% 50%
GO:0006970 Response to osmotic stress A change in state or activity of a cell as a result of an increase or decrease in the concentration of solutes outside the cell. 21% 28% 35% 50%
GO:0006950 Response to stress A change in state or activity of a cell or an organism as a result of a disturbance in organismal or cellular homeostasis. - 31% 46% 46%
GO:0006979 Response to oxidative stress A change in state or activity of a cell or an organism as a result of oxidative stress. - 3% 20% 45%
GO:0009432 SOS response An error-prone process for repairing damaged microbial DNA. - 23% 30% 45%
GO:0046677 Response to antibiotic A change in state or activity of a cell or an organism as a result of an antibiotic stimulus. - 23% 30% 15%
GO:0042493 Response to drug A change in state or activity of a cell or an organism as a result of a drug stimulus. - 15% 35% 11%
GO:0009266 Response to temperature stimulus A change in state or activity of a cell or an organism as a result of a temperature stimulus. - - 9% 11%
GO:0042742 Defense response to bacterium Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. 14% 26% 9% 8%
GO:0015968 Stringent response A specific global change in the metabolism of a bacterial cell as a result of starvation. - 13% 7% 6%
GO:0009408 Response to heat A change in state or activity of a cell or an organism as a result of a heat stimulus. - 3% 13% 5%
GO:0009409 Response to cold A change in state or activity of a cell or an organism as a result of a cold stimulus. - - - 3%
GO:0009636 Response to toxin A change in state or activity of a cell or an organism as a result of a toxin stimulus. - - - 3%
GO:0009267 Cellular response to starvation A change in state or activity of a cell as a result of deprivation of nourishment. - - - 1%
GO:0046688 Response to copper ion A change in state or activity of a cell or an organism as a result of a copper ion stimulus. - - - 1%
GO:0009269 Response to desiccation A change in state or activity of a cell or an organism as a result of a desiccation stimulus. - - 4% -
GO:0031427 Response to methotrexate A change in state or activity of a cell or an organism as a result of a methotrexate stimulus. - - 2% -
  1. The frequency of annotation of stress response-related concepts was estimated for documents published in the four decades analysed (from 1970 to 2009).