Figure 5

Functional modules. Determination of biological modules more represented in the regulatory machinery of P. aeruginosa. A) Using a short path metric distance 1/D² where Dis the distance between two nodes. White color represents interactions with D = 1, purple color shows the interactions with D = 2, interactions with D = 3are displayed in blue, with diminishing intensity as distance increases until a light blue color, representing interactions that do not exist. B) The major clusters of biological functions were also identified by analyzing the scientific literature: quorum sensing (pink), alginate biosynthesis (orange), iron metabolic (violet), nitrogen metabolic (cyan), motility (yellow), antibiotics resistance (red), expression of virulence factors (sky blue), biofilm formation (purple) and amino acid metabolism (gray). For the sake of comparison between both approaches, the same colors were used for the regulatory machinery in both figures.